people Scientists at Cambridge University have revealed are more susceptible to infection at certain times of day .
Then said the virus can be ten times more effective if the infection started in the morning
This may explain why people who do shift work -. They are at night and sleep during the day – or those who are jet lag are more likely to get sick.
This is because the body clock, which is a 24-hour pattern, affects the ability of the virus to spread between cells.
The researchers found people in a resting phase – or having an altered biological clock might be most likely affected by the virus.
Scientists say the findings, published in the Proceedings of the National Academy of Sciences, could lead to new methods stop pandemics, such as yellow fever or Zika.
When a virus enters the body, it attacks the cells and makes them replicate and spread
resources cells fluctuate throughout the day, partly in response to our rhythms circadian -. Our biological clock – which controls functions including sleep patterns, body temperature, our immune system and hormone release.
Study in mice was infected with herpes creatures at different times of the day, scientists measure levels of infection and spread of the virus.
experiment in mice lacking Bmal1 gene, which helps control the body clock, and found high levels of virus replication, regardless of the time of infection was repeated.
mice lived in a controlled environment where 12 hours were during the day and 12 hours were dark
researchers found that virus replication in infected mice at the beginning of the day -. equivalent to sunrise, when these nocturnal animals start their resting phase – was 10 times higher than in infected mice 10 hours a day, when they are transitioning to the active phase
professor Akhilesh Reddy, lead author. study, he said: “The time of day of infection can have a major influence on how susceptible we are to disease, or at least in viral replication, which means that the infection at the wrong time of day may cause much more severe acute infection.
“This is consistent with recent studies that have shown that the time of day that the flu vaccine is administered may influence how well it works.”
research was conducted at the Wellcome Trust -medical research Institute of metabolic Science at the University of Cambridge
Dr. Rachel Edgar, the first author, said: “This indicates that shift workers, working some nights and rest some nights and therefore have a disturbed body clock, it will be more susceptible to viral diseases.
“If so, then they could be prime candidates to receive annual flu shots.”
genes that control the biological clock also undergo seasonal variations, and are less active in the winter months, when diseases like influenza are more likely to spread through populations.
researchers hope that the molecular machinery of the body clock may offer the potential of new drugs to help fight infection.
This comes after it was revealed that the virus Zika sperm can remain for up to six weeks.