Our biological clocks the virus’ ability to replicate and spread accelerates between cells ten times faster during the morning than at the end of the day, putting people at greater risk of catching infection, a study involving an Indian origin scientist has revealed.
Disruptions in the main body clock to enhanced replication and spread of virus, indicating that the severity of acute infections is influenced by circadian time-keeping.
“The time of day of infection can have a major influence on how susceptible we are to disease, or at least in viral replication, which means that the infection at the wrong time of day might cause a much more serious acute infection, “said Akhilesh Reddy, a professor at the University of Cambridge.
For the study, the team compared normal mice ” wild type infected with the herpes virus and influenza virus A at different times of day, measuring the levels of infection and spread of the virus .
The mice lived in a controlled environment where 12 hours were in daylight and the other 12 hours were dark.
The results showed that virus replication in infected at the start of the day mice, when these nocturnal animals begin their resting phase, the risk of infection was shown to be ten times that infected persons the end of the day while they were making the transition to the active phase.
The suppression of cellular circadian rhythms increased both the herpes virus and influenza infection in mice, the researchers said.
“Our results suggest that the clock in each cell determines how successfully replicate a virus When we stopped the biological clock in cells or mice, it was found that the time of infection did not matter. – Viral replication was always high, “said Rachel Edgar of the University of Cambridge
” This indicates that shift workers, who work for a few nights and the rest for other nights and have a disrupted biological clock, will be more susceptible to viral diseases. If so, then they could be prime candidates to receive annual flu shots, “Rachel said.
In addition, Bmal1 – a gene that controls the circadian rhythm – also undergoes seasonal variations. , Is less active during the winter while increasing activity in summer, which explains why diseases such as influenza, are more likely to spread throughout the population during the winter, according to the article published in the journal Proceedings of the National Academy of Sciences (PNAS).
study :. University of Cambridge
RESEARCHER : Akhilesh Reddy, a professor at the University of Cambridge
study published by : journal Proceedings of the National Academy of Sciences (PNAS).