The study led by Christine Beeton at Baylor College of Medicine in the US It shows that the nanoparticles modified with polyethylene glycol (PEG) are conveniently demanding, since they are taken up by cells of the immune system.
That could be an advantage for patients with autoimmune diseases such as multiple sclerosis, researchers said.
“placed under the skin, the carbon-based particles form a dark stain fades for about a week, and slowly released into the circulation,” Beeton said.
cells and macrophages T lymphocytes and B are key components of the immune system. However, in many autoimmune diseases such as multiple sclerosis, T cells are the main protagonists. One possible cause is that T cells lose their ability to distinguish between healthy tissue and invaders and attack them.
In tests, the nanoparticles were internalized by T cells, which inhibit its function, but ignored by macrophages. “The ability to selectively inhibit a cell type over others in the same environment can help doctors to gain greater control over autoimmune diseases,” Beeton said.
“Most current treatments are not general, broad-spectrum immunosuppressants,” said Redwan Huq, lead author of the study and a graduate student in the laboratory of Beeton. “They will affect all of these cells, but patients are exposed to the side effects of infections to an increased likelihood of developing cancer. So we were excited when we see something new that could potentially allow selectivity,” Huq said.
Soluble nanoparticles synthesized at Rice University in the US have shown signs of acute toxicity in rodents previous studies, he said.
Combine hydrophilic polyethylene glycol with carbon clusters (PEG-HCC). They are carbon clusters 35 nanometers long, and three nanometers wide one atom thick, and greater to about 100 nanometers of globular.
have proven to be effective scavengers of reactive oxygen species called superoxide molecules, which are expressed by cells of the immune system uses to kill invading microorganisms.
T cells use superoxide in a step signaling to activate. PEG-superoxide HCC remove this from T cells, preventing activation without killing the cells.
Laboratory tests Baylor animal models showed that small amounts of PEG-HCC injected under the skin gradually taken by T lymphocytes, which are collected and inhibit cell function.
also they found that the nanoparticles do not remain on T cells and are dispersed within days after absorption by cells. The research was published in the scientific magazine reports.
Study: Baylor College of Medicine in the US
Principal Investigator: Christine Beeton, Baylor College of Medicine, USA
study published by :. Scientific Reports Magazine