Researchers in the US They have recently developed a new drug that can be applied directly into the eye through a dropper to shrink and dissolve cataracts -. The main cause of vision loss in humans
While the effects have not yet been tested in people, the team from the University of California, San Diego wants to double the results of medical tests and provide an option for the only treatment that is currently offered to patients with cataracts – nasty and often prohibitively expensive surgical treatment.
Impact on countless people worldwide, cataracts trigger the lens of the eye gradually becomes cloudy, and when left untreated, can cause blindness. This happens when the structure of crystallin proteins that make eye lens weakens activation damaged or disrupted to clump and form a milky blue or brown coat proteins. While cataracts can not spread from one eye to the other, they can happen individually in both eyes.
Scientists are not quite sure exactly what causes cataracts, but most cases have been reduced to age, with the US National Eye Institute reports that at the age of 80 years, most Americans have a cataract, or actually have had cataract surgery. While unpleasant, surgery to remove a cataract is extremely simple and safe, but many communities in developing countries and local areas do not have access to cash or centers to carry it out, which means the loss of sight it is inevitable for the vast majority of patients.
according to Fred Hollows structure, the approach in 32.4 million people worldwide are blind today, and 90 percent of them live in developing nations. More than half of these cases were caused by cataracts, which means they have an eye drop as an option for surgical treatment would make a great distinction.
The new drug is based on a naturally occurring steroid called lanosterol. The idea to test the effectiveness of lanosterol over the falls meant the researchers when they realized 2 children in China who had acquired a genetic form of cataract, which had never impacted their parents. The scientists found that these brothers share an anomaly that lanosterol production stopped, his parents did not have.
So if mothers and fathers were producing lanosterol and did not get cataracts, but their children were not producing lanosterol and did get cataracts, scientists proposed that the steroid may stop proteins malfunctioning crystallin clumping and forming cataracts in non -congenital type of disease.
his eyes was tested based lanosterol falls into three types of experiments. They try crystalline human in the laboratory and saw a reduction in the size of cataracts. They then tested the effects in rabbits, and in accordance with Hanae Armitage Science Mag, after six days, all but 2 of his 13 test subjects had really gone from severe cataracts mild cataracts or any falls at all. Finally, eyedrops in pets with cataracts naturally occurring tested. Like the human lens in the laboratory and rabbits, dogs reacted favorably to the drug, with severe cataracts falling into nothing, or almost nothing.
The results have been published in the journal Nature.
“This is a very extensive and attractive document – the strongest I’ve seen of this kind in a year,” molecular biologist Jonathan King, the Massachusetts Institute of Innovation (MIT) Armitage said. While not associated with this study, the king has in fact been involved in cataract research study over the past 15 years. “They discovered phenomena and thereafter followed with all experiments that you should do -. That is biologically relevant as you can get”
The next action is for scientists to figure out exactly how the eye drops lanosterol- based are generating this reaction proteins cataract, and to advance their research study to human trials.
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