One in 10 children with HIV have an immune system ‘ape-like’ that protects them from developing AIDS, according to a new study that may lead to new therapies based on immunity to the deadly infection.
HIV infection in children leads to death of 60 percent of them within two and a half years old. The same infection in monkeys is not fatal.
HIV finally ends with the immune system, making the body vulnerable to other infections and leading to the development of AIDS.
The study investigators, including the University of Oxford in the UK, was conducted on 170 children with HIV in South Africa. These children never had antiretroviral therapy, but had not developed AIDS.
researchers said that each milliliter of blood of these children had hundreds of thousands of human immunodeficiency virus, but never fell ill, ‘BBC News’ reported.
“Essentially, your immune system is ignoring the virus as much as possible. Waging war against the virus is in most cases, the wrong thing to do,” said Philip Goulder, one of the researchers Oxford University. .
“Counter-intuitive, without attacking the virus appears to save the immune system HIV kills white blood cells – the warriors of the immune system, and when the body’s defenses are in full swing, even more of them can be killed by chronic levels of inflammation, “Goulder
“One of the things that comes out of this study is that HIV disease is not so much to do with HIV, but with the immune response to it,” said Goulder.
immune system of these children responded to HIV in a similar way as 40 species of non-human primates to deal with simian immunodeficiency virus (SIV), the researchers said.
“Natural selection has worked in these cases, and the mechanism is very similar to that of these children who do not progress,” Goulder said.
The study was published in the journal Science Translational Medicine.