The gene associated with age-related conditions such as hearing loss, retinal degeneration and osteoarthritis found in a large screening program mice.
findings may lead to explore for the equivalent human gene and help develop screening programs to identify the risk of developing age-related many years before disease symptoms appear.
This is one of the first studies to examine how genes influence age-related conditions.
was also the first study linking a defective gene, Slc4a10 to hearing loss related to age, although since it is known that affect the function of the eye.
age is a risk factor for many diseases, including diabetes, cardiovascular disease, hearing loss, dementia and others, and the genes that we can influence whether we are more or less susceptible to these.
researchers from the Medical Research Council (MRC) Harwell introduced new mutations at random positions in the genes of mice before birth, and their health will be monitored as they aged.
If an age-related condition developed, the researchers investigated what particular gene in the mouse had been mutated.
Slc4a10 identifying and other related conditions late onset in mice could now prompt investigation of these genes in humans to ask whether naturally occurring mutations they cause similar effects.
in the future, inspection of persons for defects in the identified genes could help predict your chances of developing a particular condition, and someday findings could inform the development of treatment or when interventions
lead researcher Dr. Paul Potter said :. “Our study is an important stepping stone to a better understanding of what genes in humans are involved in conditions related to age, and how changes in genes that influence this.
“. this is an essential first step in the development of new therapies,”
Dr. Lindsay Wilson, Program director of Genetics and genomics said: “as we age, we have a greater risk of developing many diseases, including diabetes, cardiovascular disease, loss and dementia hear
. “the genes that we can influence this, but it’s hard to know what to do or how.
” this study increases our understanding of genes related to aging and poor health and ultimately may help us identify new treatments. “
the study was published in Nature Communications.