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Interstitial cystitis treatment may improve with molecular biomarkers: Study

By: Bel Marra Health | bladder | Saturday, August 20, 2016 – 9:30 a.m.


treatment of interstitial cystitis can improve with molecular biomarkers. The study’s lead author, said Stephen J. Walker “We are seeking molecular biomarkers for IC [interstitial cystitis], which basically means that we are comparing tissue from the bladder biopsy of patients with suspected interstitial cystitis with patients without the disease. the aim is to identify factors that lead to a more definitive diagnosis, and then use this information to tailor treatments to the patient. ”

The co-author Robert J. Evans added : “This is the first study to document genomic variation based solely on functional bladder capacity Interstitial cystitis is very difficult. diagnose. in fact, a report found that taking the average of eight years patient and see five doctors diagnose correctly. the identification of biomarkers to improve diagnosis or treatment would be a significant advance for patients and physicians. “

the study results are significant differences in gene expression in patients with low bladder capacity and two patients with normal bladder capacity, or without interstitial cystitis we were identified. In patients with low bladder capacity, genes associated with inflammation and immune signaling is activated, suggesting crucial differences in disease processes.

What is interstitial cystitis?

Interstitial cystitis (painful bladder syndrome) is a condition that affects the bladder and pelvic region. It can lead to pain, and the need to urinate a lot. Women in particular are prone to interstitial cystitis, and unfortunately, this condition does not respond to antibiotics.

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There is no cure for interstitial cystitis, and as you can imagine, the need to urinate can really put a stop to the daily routine. However, there are treatments that can help in reducing the severity of symptoms.

Causes, symptoms and complications of interstitial cystitis

There are currently no known cause for interstitial cystitis, although some conditions have been linked to the onset of disease . These conditions include having an autoimmune disorder, being prone to allergies, you have a disease of the blood vessels or defects in the lining of the bladder, and having an abnormal substance in the urine.

Interstitial cystitis can be quite painful. Symptoms include:

  • The pain of mild to moderate in and around the bladder and pelvis
  • Urgency to urinate
  • Urination frequent
  • the pain experienced during intercourse and menstruation of women
  • pain in the scrotum or penis for men

complications resulting from interstitial cystitis include reduced bladder capacity, lower quality of life, problems of sexual intimacy, and emotional problems.

Diagnosis and treatment of interstitial cystitis

The diagnosis of interstitial cystitis can be difficult, because it mimics a bacterial infection when in fact, no bacteria are present. (That is why antibiotics can not treat). Multiple tests can be performed to detect interstitial cystitis, including biopsies, urine and cystoscopy (a procedure to take a look inside your urinary tract to detect abnormalities).

Although there is no cure for interstitial cystitis, treatments are available. Symptoms can disappear based on changes in lifestyle such as wearing loose clothing to avoid added pressure to the bladder, not smoking, reducing stress, exercising and eat a balanced diet .

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Medically speaking, antidepressants, antihistamines, physical therapy, nerve stimulation, and instillation of the bladder – filling the bladder with medicine – are some forms of treatment that can help reduce the severity of symptoms for more manageable life

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living with interstitial cystitis

interstitial cystitis is not a condition life-threatening, but it can certainly alter one’s life. The need for constant visits to the bathroom and anxiety can create some uncomfortable situations. It is important to create mechanisms of survival when you are living with interstitial cystitis. This can start by reaching out to family and friends. Once they understand their condition, they can provide support.

Another effective to live with interstitial cystitis way is to keep a bladder diary and noting what some of the triggers of the bladder are. Food can be documented or activities you enjoyed in relation to the presence of symptoms. This will help you understand how your diet, and even the stress level is affecting your symptoms. You can even bring the diary with you to your appointments to review with your doctor.

be with interstitial cystitis possible, although certain lifestyle changes are needed. It can be frustrating at first, since the diagnosis of this condition is a challenge, but once diagnosed, can make the necessary adjustments for a healthy and active life.


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