Forward in search of elusive therapies against the disease nonalcoholic fatty liver (NASH), the condition most common liver around the world, Indian researchers have discovered a new mechanism through which the liver captures the extra fat from sources other than alcohol.
have also identified a new drug target brand for potential therapy for the disease, which tends to develop in people who are overweight or obese or have type 2 diabetes
NAFLD affects more than 30 percent Indian adults and occurs when more than 5 to 10 percent liver weight is fat.
there is no definitive therapy for the disease.
Moreover, a significant number of patients with NAFLD progress in the most extreme form of the disease called nonalcoholic steatohepatitis (NASH), an irreversible clinical condition that causes the liver to become inflamed and damaged and the trigger cirrhosis in adults.
principal investigator of the research group Partha Chakrabarti, along with laboratory Saikat Chakrabarti at the Indian Institute of Chemical Biology, a unit of CSIR, decided to take a shot at, paralyzing silent disease that evolves decades its prevalence advantaged with low public awareness.
literally copped his eyes on the protein degradation machinery of the cell to zero in the COP1 target protein.
“multiple molecular mechanisms are thought to cause NAFLD have arisen over the years. However, it is not yet clear whether COP1 can stop the progression of the disease or can prevent NASH. Currently we are working in this direction, “said Chakrabarti.
The study was published in September in the journal Diabetes, the American Diabetes Association (ADA).
According to the CSIR-IICB Director Samit Chattopadhyay, development will encourage the scientific community to come up with new solutions to this global problem and is “oriented toward the goal of India delivering results of translational research in the nation. ”
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