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Fungus Found Inside Humans Identified For The First Time As Key Contributor In Crohn’s Disease

Crohn disease is one of the most common forms of inflammatory disorders bowel.

While the triggers that cause the condition to explode, the exact cause of Crohn’s disease is unknown ( 1 ) are not known.

unfortunately, there is no cure for the disease, which can cause diarrhea, fever and fatigue, abdominal pain and cramping, bloody sores in the mouth, loss of appetite and loss weight, and perianal disease. Instead, patients are advised to manage their symptoms as best you can.

In Crohn’s disease, most people experience inflammation only in the last segment of the small intestine (ileum). However, it can also affect colon ( 2 ).

While some asthma attacks can be gradual, giving you time to get home to control their symptoms, others have no warning. Worse, the disease can even go into periods of remission and restart without any obvious reason.

According to estimates, about 780,000 Americans suffer from the debilitating disease ( 3 ).

Crohn’s disease 😕 a fungal infection

scientists know that intestinal bacteria can contribute to the development of Crohn’s disease, but the exact mechanism is still unknown. Fortunately, a new study from Case Western Reserve University found that this fungus can also play a role in the condition ( 4 ).

-mBio In the published study, researchers used fecal samples to assess bacteria and fungi of people with Crohn’s disease. They found that patients with Crohn’s disease had two bacteria present in feces – E. coli and Serratia marcescens. tube tests confirmed that these bacteria, fungus with Candida tropicalis, create a biofilm in the small intestine causing inflammation ( 5 ).

“The fungus is found as a colonizer in our gut. Change in the microbiota caused by a number of factors, including the use of antibiotics it allows this fungus to thrive and begin to cause problems, “says Mahmoud A. Ghannoum, Ph.D., professor and director of the Center for medical Mycology at Case Western Reserve and University Hospitals Case ( 6 ) medical Center.

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“we know that bacteria, in addition to genetic and dietary factors play an important role in causing Crohn’s disease,” he said.

“in essence, patients with Crohn’s disease have abnormal immune responses to these bacteria, which live in the intestines of all people. Although most researchers their research on these bacteria focus, few have . examined the role of fungi, which are also present in the intestines of all “

a family affair

the results were then compared to the first; first-degree relatives who had the disease. The study involved a total of 69 people from 13 families in France and Belgium.

The researchers found that the presence of bacteria and fungi were higher in people with Crohn’s disease than in their healthy relatives. The researchers also noted that beneficial bacteria were lower in affected patients. . These results were compared with families not affected by Crohn’s disease

Professor Ghannoum, who led the study, said in a press release: “Among hundreds of species of bacteria and fungi that live in the intestines, it is revealing that the three identified were so highly correlated in patients with Crohn’s disease. “

” families also have found strong similarities in what we might call the “profiles guts’ of the families of Crohn affected, which were significantly different from those of Crohn-free. “

” we must be careful, however, not attributed exclusively Crohn’s disease to bacterial and fungal our intestines makeups. For example, we know that family members also share diet and environment in significant degrees. More research is needed to be even more specific in identifying taxpayers precipitators and Crohn’s disease. “

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Specialists respond

In response to the study, Dr. Wendy Edwards, research manager Crohn’s disease and ulcerative UK, said:”. We welcome the results of this research gives further evidence as to the role that fungi can play in the cause of Crohn’s disease “

” even though the sample size of the patients in this study is small, it has highlighted a potentially interesting area for future research … Crohn’s and Colitis UK disease also are currently funding work in this important area in order to further advance our understanding of the whole world of bacteria and fungi and the role in Crohn’s disease. “

Dr. Jean Frederic Colombel, a gastroenterologist at Mount Sinai Hospital in New York, also participated in the investigation

He said,”. Although fungi have been known to be of our body, this study sheds more light on the role it can play … Perhaps in the future if we treat patients with Crohn’s disease … we think not only its bacteria, but also fungi, “he said Health Line.

future treatment of Crohn’s disease

researchers noted that this was the first time a fungus has been associated with Crohn’s disease in humans, although previously observed in mice. it is also the first time that Serratia marcescens was potentially involved in the symptoms of the disease.

Because the study conducted in a small group of patients in two European countries, critics believe that more research is needed to see if these results apply to patients in other countries.

Before the study, it was believed that the disease Crohn be due to heredity and an immune system that does not work. This new information may lead to new treatment options for patients living with Crohn’s disease.

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