London: Researchers have found a possible new way to stop one of the most aggressive types of Brain tumor spreading, which could also open the way to a better patient survival [
Glioblastoma, which is one of the most common types of malignant brain tumors in adults, grow quickly and spread easily.
The tumor has threadlike tendrils spread to other parts of the brain so it is difficult to remove all, the study by the University of Southampton in Britain, said.
The results suggest that by blocking specific enzymes called ADAM10 and ADAM17, the tumor can stop the growth and spread.
as leading to cancer cells away from where they were growing up which could allow them to be removed through traditional cancer treatments such as radiotherapy, chemotherapy or surgery, the researchers said.
“Glioblastoma is a devastating disease that is often untreatable. We found that blocking ADAM can lead to a reduced and less recurrent tumor growth after conventional treatments, improving the chances of complete surgical removal and improve survival rates, “said Sandrine Willaime-Morawek, professor at the University of Southampton in Britain.
Current treatment regimens are ineffective against small population of cancer stem cells that reside in the carcinogenic niche.
These tumors are highly proliferative and invasive resulting in a median patient survival of only 14 months from diagnosis.
However, the new therapeutic approach could involve the removal of these cells from microenvironment that maintains the phenotype of cancer stem cells, the researchers concluded in the study published in the journal Molecular Neurobiology.