Excess sugar consumption – specifically fructose sugar and soda -. It has been linked to an increase in metabolic diseases worldwide, a study has found
Some researchers argue that the amounts of habitual consumption of sugar not contribute to this epidemic. While others are convinced that excessive sugar intake is one of the main causes.
“There is still significant as to whether sugar consumption is a major contributor to the development of diabetes controversy,” said lead author Mark Herman, assistant professor at Duke University.
However, “the study reveals a specific mechanism by which fructose consumption in large quantities, such as soda, can cause problems,” Herman said.
Insulin is a key hormone that regulates blood glucose after eating. insulin resistance, when metabolic body tissues typically fail to respond to insulin, is one of the earliest detectable changes in the progression of diabetes.
The probable cause of insulin resistance can not be the accumulation of fat in the liver, as is commonly believed, but can be caused by excess sugar in the liver that activates a molecular factor called element binding protein carbohydrate responding, or ChREBP.
ChREBP can then contribute to the development of both fatty increased glucose production in the liver and, according to the researchers.
The ChREBP protein is found in several metabolic organs in mice, humans and other mammals.
“We found that no matter how much insulin the pancreas Made, could not invalidate the proceedings initiated by this protein, ChREBP, to stimulate the production of glucose. This ultimately make sugar levels in the and increased blood insulin, which can eventually lead to insulin resistance in the body elsewhere, “said Herman.
to test their hypothesis, the researchers studied mice that were genetically altered to your liver signaling pathways of insulin activates the most -. in other words, their livers should not have been able to produce any amount of glucose
researchers found that even in these mice, eating fructose triggers related ChREBP-liver processes, causing it to become more and more glucose, despite insulin signals telling them to stop.
Previous studies have reported that high fructose diets can cause various metabolic problems in humans and animals, including insulin resistance and fatty liver disease.
The finding could also help scientists one day diagnose metabolic disorders before, potentially allowing patients to make changes in their diets and lifestyles early to avoid more serious complications.
the study published in the Journal of Clinical Investigation.