Seoul researchers including one of Indian origin, have developed an electrical immunosensor for early detection of heart attack, which provides results in just a minute, reports PTI
heart disease is the leading cause death in men and women. Therefore, a rapid and reliable diagnosis of heart attack is urgently needed, the researchers said. The system works by measuring the level of cardiac troponin I (cTnI), a protein that is secreted by the heart muscle blood after a heart attack.
“This new inmunosensor is constructed differently than any other sensor. Due to the new design of this immunosensor, this device is able to quickly diagnose the level of heart attacks at the point of care,” said Jang Jaesung the National Institute of Science and Technology (UNIST) Ulsan in South Korea.
The use of a single drop of blood, this immunosensor detects the target protein present in blood serum after a heart attack and gives a result in a minute. In the study, dielectrophoretic forces (DEP) applied to attract the target protein. Incubation time required for detection is reduced by the concentration of biomarker mediated DEP.
Therefore, the concentration of cTnI dielectrophoretic reduced the incubation time required 60 minutes and one minute, the researchers said. “The level of cTnI within a single drop of blood serum is not very large. However, we were able to attract the target protein in the areas of detection through electrical forces, thus greatly improve the detection time and detection limit “Han Chang-Ho UNIST said.
According to the researchers, including Abhinav Sharma UNIST, this inmunosensor novel has considerable potential for use as a platform to detect different types of protein, along with the possibility of miniaturization and integration for biomedical diagnostics. The findings were published in the journal Biosensors and Bioelectronics.