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Common pain killers increase heart failure risk

Natural Health News – Anti-inflammatory drugs are among the most commonly used and are primarily used to relieve pain and the inflammation.

Based on the real-world data from four European countries and nearly 10 million people using a wide range of non-steroidal anti-inflammatory drugs (NSAIDs), including COX-2 inhibitors (a new generation of NSAIDs commonly prescribed for arthritis pain).

The milestone in analysis British Medical Journal found that NSAIDs increase the risk of hospitalization for heart failure and that the magnitude of risk varied between individual NSAIDs and in accordance with the prescribed doses.

Although not the first study to show an association such, it is definitely one of the biggest.

What you need to know

CA reanalysis of data across Europe has found a link between drugs nonsteroidal commonly used anti-inflammatory drugs (NSAIDs) and the risk heart failure

The risk was strongest among those who had recently taken drugs – those who had taken drugs in the last 19 days were a 19 % more likely to be admitted to hospital with heart failure.

While this is not the first study on NSAID linked with heart problems is the largest and highlights the problems of a whole class of drugs that was launched without thorough testing or regulatory oversight.

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9 common drugs involved

The risk of hospitalization for heart failure increased over seven traditional NSAIDs (diclofenac, ibuprofen, indomethacin, ketorolac, naproxen, nimesulide and piroxicam) and two COX-2 (etoricoxib and rofecoxib). The increased risk of hospitalization ranged from 16% to 83% naproxen and ketorolac.

Overall, the researchers found users of current NSAID (defined as individuals who had used NSAIDs in the last 14 days) were 19% more likely to be admitted to hospital with heart failure that past users (individuals they had not used NSAIDs for at least 183 days).

A particular concern was that NSAIDs common, such as ibuprofen, diclofenac and naproxen use were associated with an increased risk of heart failure and the use of high doses of ibuprofen and diclofenac doubled the odds, although the increase risk associated with the use of high dose naproxen was slightly lower.

In contrast to other selective COX-2 inhibitors (eg, rofecoxib, etirocoxib), celecoxib were not associated with an increased risk of heart failure. But celecoxib is used primarily in low doses, so the safety of higher doses of celecoxib remains unexplored.

Researchers say the new data “provides further evidence that traditional individual NSAIDs frequently used and COX-2 inhibitor are associated with an increased risk of hospitalization for heart failure. In addition, the risk seems vary between drugs and according to the dose. ”

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Previous studies highlight the problems

Several studies have previously shown links between NSAIDs and health problems.

Earlier this year an analysis European Heart Journal found that inhibitors of Cox-2 also increased the risk of other health problems, including ulcers and increased blood pressure.

A 2014 study BMJ Open found a significant increase of irregular heartbeat (atrial fibrillation fibrilliation) in older adults who take NSAIDs. Current use was associated with a 76% increased risk of atrial fibrillation never use, after taking into account other risk factors such as age, sex and underlying cardiovascular problems. Similarly, the recent (with 30 days prior) of these drugs was linked to a 84% higher risk of atrial fibrillation.

Also in 2014 an analysis in the journal Rheumatology found that the use of NSAIDs (aspirin and ibuprofen), almost double the risk of deep vein thrombosis (DVT) and pulmonary embolism, two lethal conditions.

A Editorial to the latest study accompanying says “NSAIDs are first introduced more than a century and most commonly used NSAIDs were recorded at a time with some documentation requirements security. therefore, for most of these drugs, there is an alarming lack of randomized studies considering their safety. ”

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