The study involved nearly 2,000 patients showed that women whose tumors had a specific pattern of activity in the two genes they were three times as likely to die within 10 years as others with a different pattern of activity.
scientists from the Institute of Cancer Research, London, saw the pattern of gene activity between cells of breast cancer with a special ability to escape the “glue” that normally held in place
believe that genes could play a key role in the release of cells from this glue -. known as the “extracellular matrix” – so it can spread around the body
The research, funded by the Institute of Cancer Research (ICR) and breast cancer now, could It is used to develop tests for aggressive breast cancers, or even to identify new targets for cancer treatment.
The study, published in the journal Oncotarget, looked at breast cancer cells that were positive for HER2 protein -. the target for the drug Herceptin, found in about 20 percent of tumors
researchers ICR developed a new technique based screening image to identify cancer cells that do not adhere to the protein laminin -. that helps build scaffolding around the cells to stick
they found that these cells tend to have high activity in a gene called F12 and low activity in another STC2 call.
When the researchers analyzed the same genes among 1,964 breast cancers, they found that the pattern of activity was strongly linked to survival.
Women whose tumors had high activity and low activity STC2 F12 had a chance to 32 percent die within 10 years.
But those with low activity and activity F12 high STC2 only had a 10 cent chance of dying.
now scientists said more research is needed to establish how genes may interfere with the extracellular matrix and help cancer cells grow and spread.
study leader Dr. Paul Huang said: “Survival rates for breast cancer are now much higher than they were a few decades ago, but the disease is still fatal once it has spread around body
. ” Our study sheds light on how cancer cells themselves UNSTICK healthy tissue, and could help distinguish women at high risk of their cancer spread and become deadly.
“We found that the activity of two genes that can help control how tightly cells are glued together is related to the survival of breast cancer.
“If the results are confirmed in larger studies, it could give us a new way to assess the chances of survival of women in the clinic, and adjust the treatment accordingly”
professor Paul Workman, CEO Institute of cancer Research, London, added: “. We have seen great advances in the treatment of breast cancer, but once it starts to spread around the body is still often fatal.
“This new study helps us understand some of the processes that control how breast cancers spread, and identifies a pattern of gene activity that could be used to pick up women particularly at risk.”